PerkinElmer

傳染病

OF

Detect disease-causing microbes, and detect and quantitate biomarkers of infectious disease, with our wide range of in vivo, in situ, cellular, and biochemical research products.

  • Monitor acute and chronic infection and therapeutic treatment in animal models in real time with our in vivo imaging systems -- and enable quantitative assessment and growth inhibition --with our bioluminescent bacterial strains.
  • Enable the fast and simple quantitative detection of specific biomarkers of infectious disease in human and plant samples with easy-to-use, pre-validated kits in our ELISA alternative technologies.
  • Gain deeper insights from phenotypic analysis with our high content screening and tissue imaging solutions.

產品與服務 (82)
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產品類型
  • Accessories (34)
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應用
  • In situ hybridization (ISH) (8)
  • Immunohistochemistry (IHC) (8)
  • Protein Analysis & Detection (7)
檢測點(200-50,000)
  • 500 (6)
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  • HBsAg (2)
  • p24 (2)
  • Influenza A NP (1)
  • HBeAg (1)
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  • 51-100 (7)
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  • Operetta (30)
  • Operetta CLS AND Opera Phenix (8)
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  • Operetta (29)
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  • Bacterial infection (14)
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1-12 的 82 產品與服務

  • 1000x1000_Opera_Phenix

    Opera Phenix 高內涵系統

    Opera Phenix?高內涵系統是目前最受期待的高內涵共聚焦技術方案。依賴將近20年的頂尖高內涵產品opera高內涵成像系統積累的豐富成像和應用經驗,新一代的opera phenix系統系統專為高內涵表型篩選以及復雜的疾病模型量身打造,例如活細胞、原代細胞,細胞微組織。
  • IVIS Lumina S5 high throughput, high sensitivity optical in vivo imaging system

    IVIS Lumina S5成像系統

    IVIS Lumina S5是PerkinElmer最新推出的第四代小動物活體光學二維成像平臺。該系統秉承了前幾代IVIS系列共有的作為業內金標準的高靈敏度生物發光成像性能,以及專利的熒光多光譜掃描及分離(Spectral unmixing)成像性能。
  • IVIS Spectrum In Vivo Imaging System

    IVIS Spectrum 小動物活體成像系統

    IVIS? Spectrum 小動物活體光學成像系統是全球首臺同時具備生物發光、熒光、化學發光及切倫科夫二維/三維成像功能的系統,代表了目前活體光學成像技術的最高水平。
  • IVIS Lumina X5 in vivo imaging system

    IVIS Lumina X5成像系統

    PerkinElmer全新一代小動物活體成像系統IVIS Lumina X5整合了最佳的高通量生物發光、熒光及高分辨率二維X光成像模塊。擴展為五只小鼠的光學及X光大成像視野、獨特的實驗設置和樣品標記輔助配件讓研究人員能更便捷、更快速地獲取疾病進展中解剖學和功能學各方面的穩定數據和答案。
  • IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

    IVIS SpectrumCT 小動物活體成像系統

    IVIS? Spectrum CT是全球頂尖的小動物活體三維光學/CT二合一成像系統。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina III 小動物活體成像系統

    IVIS? Lumina III是PerkinElmer最新推出的第三代高靈敏度多光譜小動物活體光學二維成像平臺。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina LT 小動物活體成像系統

    IVIS? Lumina LT是PerkinElmer最新推出的第三代高靈敏度小動物活體光學二維成像平臺。
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS 小動物活體成像系統

    IVIS? Lumina XRMS III是PerkinElmer最新推出的二維多模式活體成像系統,具備最高靈敏度的生物發光、多光譜熒光、放射性同位素和X光活體成像功能。
  • AlphaLISA immunoassay kits

    Influenza A Nucleoprotein (NP) AlphaLISA Detection Kit

    The AlphaLISA? immunoassay kit for influenza A nucleoprotein (NP) enables the quantitative determination of nucleoprotein in buffered solution and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
  • AlphaLISA immunoassay kits

    HIV p24 (high sensitivity) AlphaLISA Detection Kit

    The AlphaLISA? Human Immunodeficiency Virus type-1 p24 protein (HIV p24) (high sensitivity) Detection Kit is designed for detection and quantitation of HIV p24 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
  • S. aureus Bioluminescent Bacteria

    Staphylococcus aureus - Xen29

    Staphylococcus aureus - Xen29 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from a parental strain from the American Type Culture Collection, used under license.?Staph. aureus-Xen29 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • AlphaLISA immunoassay kits

    Hepatitis B Virus s Antigen (HBsAg) AlphaLISA Detection Kit

    The AlphaLISA? immunoDetection Kit for Hepatitis B Virus Surface antigen (HBsAg) enables the quantitative determination of HBsAg in cell culture media and buffer using a homogeneous AlphaLISA assay (no wash steps).
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Business Insights (14)
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資源庫
  • Application Note (10)
  • Poster (3)
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1-12 的 14 Business Insights

  • 白皮書

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • 應用文獻

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 應用文獻

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 應用文獻

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 應用文獻

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 應用文獻

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 應用文獻

    用高內涵篩選系統進行FRET測定

    在這個實驗中,我們建立了一種快速穩定的基于FRET的高內涵檢測...

  • 應用文獻

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • 應用文獻

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 應用文獻

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • 應用文獻

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • 海報

    In vivo fluorescent imaging of tumor bombesin and transferrin receptor expression as early indicators of sorafenib efficacy in small animal models

    Targeted cancer therapy aims to block key signaling pathways that are critical for tumor cell growth and survival. The blockage eventually results in cell death via apoptosis and eventual tumor growth suppression. This strategy has proven to be quite effective, and the FDA has approved several targeted therapeutics in the past decade. Encouraged by the success in clinical development, many academic and pharmaceutical researchers are in active pursuit of improved next generation targeted anti-cancer drugs. As a result, many new chemical and biological entities are emerging from initial screening of in vitro, in vitro and/or in silico selection processes. From the perspective of drug development, it poses a great challenge for the next stage of in vivo validation and demands a robust, accurate, and efficient method for assessment of these candidates in living animal models.

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