PerkinElmer
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單細胞分析

測量細胞對金屬成分的攝取的傳統方法可能是一個比較耗時的過程,需要長時間的儀器分析和樣品制備,而且通常只能得到定性或總體平均結果。

NexION? ICP-MS單細胞分析系統曾屢獲殊榮,配備專有的Asperon?單細胞霧室、單細胞Micro DX自動進樣器和Syngistix?單細胞軟件模塊,能夠幫助定量測量單個細胞中的金屬含量,推出的全新功能可以研究內在金屬和細胞吸收溶解態(離子型)和納米顆粒態金屬,從而從新的角度深刻了解藥物釋放、毒性評估、生物有效性和生物累積機制。

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癌癥研究

金屬類抗癌藥物已使用多年,使用最為廣泛的是鉑類藥物。癌癥治療的功效與每個癌細胞相互作用的藥物量有關。傳統的藥物研究技術僅限于對同一組細胞的測量,在進行定量分析時,需要對特定細胞群進行同質化。細胞群是異質的,甚至同一細胞群和細胞株的細胞也存在差異。

使用單細胞ICP-MS,能夠精確地測定單個細胞中的藥物含量,從而得出細胞群的直方圖,這樣便可體現出細胞群中最常見的藥物含量和藥物平均量,以及藥物在整個細胞群中的分布情況。單細胞ICP-MS是研究細胞耐藥性的一種重要工具,有助于更好地了解遷移/停留機制。

藥品/藥物研發

幾千年來,金屬和金屬化合物在醫學中得到了廣泛應用。有些是發揮作為酶中的輔因子或修復物之正常功能所必不可少的,有些在診斷中用作放射性同位素成像劑或醫學成像的造影劑,有些則用于治療。如果您的研究方向是金屬和金屬化合物的開發和使用,并且希望更好地了解這些藥物與靶細胞相互作用的機制,使用單細胞ICP-MS能夠精確地測定細胞水平的吸收劑量,揭示重要的機理信息。

環境毒理學

環境毒理學是將毒理學和環境科學融合在一起的跨學科領域,研究對象是有毒化學物質在群體、群落、生態系統和生物圈水平上對生物有機體產生的影響。已使用生物有機體在細胞群和群落水平上對許多金屬、有機金屬化合物和最近的納米材料進行了生態毒理學研究,但缺少細胞水平上吸收劑量和接觸途徑的關鍵機理信息。使用單細胞ICP-MS能夠精確地測定細胞水平的吸收劑量,揭示生物系統多樣性的重要信息。還能夠確定每個細胞所攝入的金屬顆粒量,從而提供前所未有的吸收劑量信息。

Single Cell Analysis Featured Products

NexION 2000 等離子體質譜儀

PerkinElmer’s NexION? 2000 is the most versatile ICP-MS on the market, feat ...

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Syngistix for ICP-MS Single Cell Application Software Module

The Syngistix? Single Cell Application Module, an extension of PerkinElmer’ ...

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Asperon Spray Chamber

The Asperon? Spray Chamber, part of PerkinElmer's award-winning NexION? ICP ...

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Single Cell Micro DX Autosampler Kit for NexION 1000/2000 ICP-MS

The Single Cell Micro DX Autosampler is a microfluidic automation platform ...

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Single Cell Sample Introduction Kit for NexION 1000/2000 ICP-MS

The Single Cell ICP-MS Sample Introduction Kits are part of PerkinElmer’s a ...

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