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NexION 2000 B ICP Mass Spectrometer

PerkinElmer’s NexION? 2000 is the most versatile ICP-MS on the market, featuring an array of unique technologies that combine to deliver the highest performance no matter what your analytical challenge. Discover the effortless versatility of an instrument that makes it easy to handle any sample matrix, any interference, and any particle size.

PerkinElmer received on April 11, 2018 the Application Award from LaborPraxis in the category Bio and Pharma Analysis for the NexION 2000 ICP-MS. We were awarded this prize during analytica 2018 in Munich, Germany, in acknowledgment of a new technique enabling users to quantify the amount of metal in an individual cell for the first time.

Part Number
Model Name
N8150044
NexION 2000 B
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N8150045
NexION 2000 C
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N8150046
NexION 2000 P
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N8150047
NexION 2000 S
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Overview

Ideal for laboratories new to ICP Mass Spectrometry, the NexION 2000 B ICP-MS features:

  • A dedicated SMARTintro? sample-introduction module simplifies operator setup, streamlining your workflows
  • Extended Dynamic Range capabilities provide the ability to detect high-and low-level elements in a single sample run
  • Three quadrupoles, three gas channels, and three modes of operation combine to offer better interference removal, delivering better detection limits/improved data accuracy
  • The industry’s fastest data acquisition speed on the market (100,000 points/sec) to handle any particle size
  • A new solid-state RF generator with revolutionary LumiCoil? technology – first ICP-MS RF coil that requires no maintenance or cooling
  • Triple Cone Interface with Quadrupole Ion Deflector, delivering no maintenance beyond the cones
  • Syngistix? software provides an intuitive interface that mirrors your workflow, with left-to-right, icon-based navigation that guides you through your analysis. Plus, it’s a cross-platform solution, easing the transition from technique to technique
  • Built-in Radian? Remote Monitoring Service with Syngistix for ICP-MS software v 2.3 or higher – provides real-time monitoring of your NexION system’s diagnostic parameters, enhancing laboratory productivity
The NexION 2000 ICP-MS – Triple Quad Power Meets Single Quad Versatility.

Specifications

21 CFR Part 11 Compatible Yes
Depth 69.0 cm
Height 75.0 cm
Model Name NexION 2000 B
Portable No
Product Brand Name NexION
Warranty 1 Year
Weight 150.0 kg
Width 81.0 cm
Resources, Events & More
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Application Note

A Single Cell-ICP-MS Method to Study the Treatment Efficiency of Algaecide for Toxic Algal Bloom Control

Toxic cyanobacterial blooms were reported worldwide in various aquatic systems, including freshwater rivers, lakes, reservoirs, and eutrophied coastal marine habitats. Cyanobacterial blooms might be caused by a combination of multiple factors, including eutrophication, solar radiation, temperature, current patterns and other associated factors. Their proliferation in aquatic environments can cause death or toxin accumulation in aquatic animals and then, indirectly or directly, affect human health. Microcystis aeruginosa (M. aeruginosa) bloom is the most common harmful algal bloom (HAB) and is widely studied in various fields.

Copper sulfate is an algaecide frequently used for controlling algae growth. The mechanism of copper (Cu)-based algaecide for algal bloom control is not well understood. The amount of Cu required to kill an individual algae cell and the morphology of the cell after being killed is still unknown. Quantification measurement of these phenomena is even more difficult due to the lack of appropriate methodology.

This work demonstrates that single cell (SC)-ICP-MS provides an effective method for the determination of copper algaecide at the cellular level, leveraging the NexION® ICP-MS with Syngistix Single Cell Application software module.

PDF 2 MB
Accurate Sizing and Precise Counting of 10 nm Gold Nanoparticles using the NexION 2000 ICP-MS

In this work, we demonstrate that PerkinElmer's NexION? 2000 ICP-MS, with its unique RF generator and ion optics, coupled with the Syngistix? Nano Application Software Module, can be used to accurately measure and characterize NP sizes of 10 nm and smaller, both alone and in a mixture of NPs of various sizes.

PDF 2 MB
Advantages of a High Throughput Sample Introduction System for Drinking Water Analyses Using ICP-MS

Water forms 80% of the human body and is essential to all life. Due to increasing pollution and land disturbance, vast quantities of potentially harmful elements are mobilized into potable water sources, such as rivers, lakes and groundwater. As such, the concentrations of elements, which are known to elicit a toxicological response, are regulated throughout the world by international and national regulations, of which one of the most commonly used methods is the United States Environmental Protection Agency 200.8 (EPA 200.8). Since all drinking waters need to be tested prior to distribution to ensure fitness for consumption, this makes sample loads on water-testing laboratories high.

This study presents a high throughput method evaluating 27 analytes in drinking water following EPA 200.8 with a 3-5 fold reduction in sample analysis time through the use of PerkinElmer’s High Throughput System (HTS), a novel high-volume sample introduction module that is fully integrated with the NexION ICP-MS.

PDF 1 MB
Analysis of Cerium Dioxide Nanoparticles in Soil Using Single Particle ICP-MS

This work demonstrates a robust method using SP-ICP-MS technology to detect CeO2 NPs which were extracted from soil samples with tetrasodium pyrophosphate (TSPP). Over the past few decades, engineered nanoparticles (ENPs) have been increasingly used in many commercial products. As a result, more and more ENPs have been released into the environment, which raises concerns over their fate, toxicity and transport therein.

PDF 1 MB
Analysis of Drinking and Natural Waters using the NexION 2000 ICP-MS

This work has demonstrated the ability of the NexION 2000 ICP-MS to analyze both natural and drinking water samples in Standard (i.e. non-cell) mode, in accordance with U.S. EPA Method 200.8. Accuracy has been demonstrated through the analysis of several reference materials and spike recoveries, with stability of at least nine hours. Method detection limits allow for trace-level determinations, while the ability to selectively suppress user-defined isotopes also allows the measurement of analyte levels usually only possible by ICP-OES or Flame AA. The NexION 2000 provides a comprehensive solution to the challenge of U.S. EPA Method 200.8 and other drinking and natural water analytical requirements across the globe.

PDF 1 MB
Analysis of Single-Walled Carbon Nanotubes with SP-ICP-MS

Measuring the amount of metals in CNTs presents a challenge. High levels can be measured directly in the solid by several techniques, including XRF and TEM, while low-level analysis requires complete digestion of the sample prior to analysis by ICP-OES or ICP-MS.

PDF 555 KB
Analysis of Soils and Waters in Accordance with U.S. EPA Method 6020B using the NexION 2000 ICP-MS

Through the years, both industry and analytical instrumentation have advanced. With the development of new chemicals and processes, new pollutants may enter the environment. However, the capabilities of analytical instruments have also increased, allowing the measurement of ever lower levels of environmental contaminants, as well as new pollutants.

PDF 2 MB
Characterization of TiO2 Nanoparticle Release from Fabrics By Single Particle ICP-MS

In the textile industry, the use of titanium dioxide (TiO2) nanoparticles (NPs) is increasing due to their ability to provide UV protection, increase the hydrophilic nature of fabrics, provide antibacterial characteristics, and reduce odors. This work demonstrates the ability of PerkinElmer's NexION® Single Particle ICP-MS with Syngistix Nano Application Software Module to both detect and measure TiO2 nanoparticles released from textiles.

PDF 516 KB
Determination of Trace Elements in Eye Drops with the NexION ICP-MS

Eye drops are commonly used medications which are available both over-the-counter and as prescriptions in various forms. Because eye drops are classified as a parenteral medication and have relatively large daily doses, the inorganic components in eye drops must be present at low concentrations. As a result, ICP-MS is the most appropriate technique for the determination of trace elements in eye drops.

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. This work discusses the sample preparation and analysis of Class 1, 2, and 3 elements in a variety of eye drops with the NexION ICP-MS, following the criteria defined in ICH Q3D. The developed methodology (both sample preparation and analytical) demonstrates both accuracy and stability.

PDF 475 KB
Digestion, Testing, and Validation of Heavy Metals in Cannabis

Owing to the toxicity of heavy metals, it is increasingly important to test cannabis flowers and other cannabis derivatives so that patient and consumer safety is maintained as the use of cannabis becomes more common. This need has translated into an increasing demand for testing cannabis flowers and other cannabis derivatives for toxins such as the heavy metals cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg). In this application note, we present data to illustrate the successful validation of the Titan MPS? Microwave Sample Preparation System and the NexION? ICP-MS for the determination of heavy metals in cannabis flower according to the validation protocols set in USP General Chapter <233>, which are commonly used for evaluation of the levels of elemental impurities in samples.

PDF 1 MB
Monitoring the Uptake of Nanoparticles and Ionic/ Dissolved Gold by Fresh Water Algae

This work demonstrates how Single Cell ICP-MS (SC-ICP-MS) can be used to monitor gold nanoparticle uptake by algae with PerkinElmer's NexION ICP-MS.

PDF 3 MB
New Research Evaluating Cisplatin Uptake in Ovarian Cancer Cells by Single Cell ICP-MS

Cisplatin, carboplatin, and oxaliplatin are the most widely used of platinum-based cancer chemotherapy drugs in the Western world. Cisplatin's effectiveness is due to its ability to bind to the DNA, resulting in DNA-platinum (Pt) adducts, which bend the DNA. The cells must then repair the DNA damage, otherwise DNA replication is blocked resulting in cell death. Many cancers are initially sensitive to platinum-based treatment, but patients frequently relapse with tumors displaying resistance to further cisplatin therapy.

PDF 2 MB
NexION 2000: A Perfect Tool for the Determination of Trace Elements in Blood and Serum

This work demonstrates the ability of PerkinElmer's NexION 2000 ICP-MS to perform accurate, stable analyses of blood and serum samples, leveraging the benefits of the Universal Cell and the ability to use three cell gases in a single method.

PDF 931 KB
Quantification of Low Levels of Hexavalent Chromium in Water Using a NexSAR HPLC-ICP-MS

Due to rising concerns over the carcinogenic properties of hexavalent chromium (Cr6+) in drinking water, many national and regional water standards are looking to lower the maximum allowable levels of total chromium and hexavalent chromium in potable waters. And in order to assess trace concentrations of Cr6+ in drinking water, it is necessary to have an instrument capable of measuring parts per trillion (ppt) concentrations of Cr and possessing a wide linear dynamic range – HPLC-ICP-MS is often the instrumentation of choice in such applications.

This work demonstrates an ion exchange method for the characterization of Cr6+ in potable drinking water using our NexSAR HPLC-ICP-MS Speciation Solution. Discover the advantages of the inert and metal-free fluid path of the NexSAR Inert HPLC coupled with the NexION® ICP-MS’ Universal Cell Technology for these types of analyses – download this application note.

PDF 1 MB
Quantification of Nanoparticle Uptake into Cancer Cells using Single Cell ICP-MS

Nanoparticles (NPs) have been of significant interest over the last two decades as they offer attractive benefits for drug delivery to overcome limitations in conventional chemotherapy. Nanoparticles can be engineered to carry both drugs and imaging probes to simultaneously detect and treat cancer. They may also be designed to specifically target diseased tissues and cells in the body. A number of nanoparticlebased cancer therapeutics have been approved for clinical use and/or are currently under development.

PDF 939 KB
Speciation of Hexavalent Chromium in Children's Toys According to EN 71-3 Category II with the NexSAR HPLC-ICP-MS

Testing for harmful metal(loid)s that may be included in raw materials, processes, paints and additives used in the manufacturing processes of children's toys has been mandated by the regulation EN 71-3. This regulation recommends specific testing methods and maximum allowable concentrations of leachable metals and metalloids such as Al, As, B, Ba, Cd, Co, Cr (III), Cr (VI), Cu, Hg, Mn, Ni, Pb, Sb, Se, Sn, organotin, Sr and Zn in parts of toys, with the exclusion of general packaging materials. This work shows a method for the measurement of hexavalent chromium in different toy material categories in accordance with method EN 71-3 Category II, leveraging the unique combination and capabilities of the NexSAR Inert HPLC coupled to the robust NexION® ICP-MS.

PDF 918 KB
Testing and Validation of Various Antacids for Elemental Impurities using the NexION 2000 ICP-MS

The United States Pharmacopeia (USP) has announced that its new standards for elemental impurities in drug products has been implemented since January 1, 2018. General Chapters <232> and <2232> specify the list of elements and their permissible daily exposure (PDE) limits based on the route of administration.

PDF 576 KB
Transport of Nanoparticles From Coated Surfaces Through Physical Contact

This work investigated the transfer of Ag and CuO nanoparticles from consumer products via simulated dermal contact by using textile wipes as a surrogate using PerkinElmer’s NexION ICP-MS single particle analyzer with the unique Syngistix Nano Application software module for data collection and analysis

PDF 1 MB

Brochure

Cannabis Testing Solutions Brochure

Learn more about our various testing methods and applications for cannabis analyses by reading through our Cannabis Testing brochure.

PDF 9 MB
Grain Testing Solutions Brochure

The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.

PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.

PDF 6 MB
NexION 2000 ICP Mass Spectrometer Brochure

PerkinElmer's NexION 2000 ICP-MS is the most versatile ICP-MS on the market, featuring an array of unique technologies that combine to deliver the highest performance no matter what your analytical challenge.

PDF 1 MB
Refinery and Natural Gas Analysis

Oil refineries and natural gas producers around the world require their lab operations to perform large numbers of analyses before their products are used in industries and by consumers. Detection of even the slightest impurities, accurate process control and hydrocarbon distribution analysis is critical to the success of these operations.That’s how PerkinElmer can help. As a global scientific leader and solutions provider to refining and natural gas labs, PerkinElmer's proven technology and experience meets the ever-changing needs of the oil and gas industry. PerkinElmer is committed to the success of your oil and gas sample analysis by providing the instrumentation, software, consumables, and services you need for fast, easy and precise testing. The result: better control of your operations and improved product quality.

PDF 5 MB
USP <232>/<233> & ICH Q3D Capabilities Brochure

The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. In combination with the U.S. Pharmacopeia’s (USP) Chapters <232> and <233> on elemental impurities, they redefined how the pharmaceutical and related supply-chain industries will measure, document, and comply with strict new standards to limit the presence of elemental impurities in drug products.

PerkinElmer provides the tools and processes you need to take control of impurities testing for both drug substances and drug products, providing proven, reliable technology for the identification and quantification of elemental impurities and the accurate measurement of residual solvents in accordance with strict regulatory guidelines.

Download this brochure to learn more.

PDF 3 MB

Catalog

Atomic Spectroscopy 2018-2019 Consumables & Supplies Catalog

With instruments that are the industry standard worldwide, PerkinElmer accessories, consumables, methods and application support meet the most demanding requirements and are the preferred choice in thousands of laboratories globally.

PDF 8 MB

Guide

Atomic Spectroscopy, A Guide to Selecting the Appropriate Technique and System

This guide provides a basic overview of the most commonly used atomic spectroscopy techniques and provides the information necessary to help you select the one that best suits your specific needs and applications.

PDF 1 MB
NexION 1000/2000 ICP-MS Consumables & Supplies Guide

Look to PerkinElmer for all of your consumables and supplies for your NexION 1000 or 2000 ICP-MS system.

PDF 1 MB
NexION 1000/2000 ICP-MS Preparing Your Laboratory

PerkinElmer ICP-MS instruments are complete systems with the exception of the following items which must be provided by the customer: electrical power, exhaust vents, argon gas supplies with approved regulator, cell gas supply with approved regulators

PDF 1 MB

Product Note

Syngistix Atomic Spectroscopy Enhanced Security Software Product Note

PerkinElmer’s Syngistix Enhanced Security software for AA, ICP and ICP-MS meets the special needs of highly regulated labs such as those that must comply with the U.S. FDA’s 21 CFR Part 11 regulations.

PDF 1 MB

Regulatory Compliance Certification

NexION 1000/2000 Product Certificate

Product Certificate for the NexION 1000/2000

PDF 44 KB

Technical Note

Advantages of a Novel Plasma Generator for the NexION 2000 ICP-MS

PerkinElmer's NexION 1000/2000’s patented RF generator combined with the novel design of the self-cooling LumiCoil RF coil provides a reliable plasma source for a wide range of demanding trace-element detection applications.

PDF 906 KB
All Matrix Solution System for NexION ICP-MS Platforms

PerkinElmer’s All Matrix Solution system provides a number of benefits to simplify analysis of high-matrix samples with the NexION family of ICP-MS instruments.

PDF 1 MB
PerkinElmer Asperon Spray Chamber-Delivering Intact Individual Cells to ICP-MS Plasma

Discover how the PerkinElmer Asperon Spray Chamber can deliver "intact individual cells" to ICP-MS Plasma.

PDF 1 MB

White Paper

Assessment of Extractables and Leachables Associated with Pharmaceutical Packaging

Extractables and leachables studies are critical for maintaining the quality of your drug product and complying with GMP regulations during drug development and final batch release. Exposure to extractables and leachables could have a detrimental impact on the safety and efficacy of a final drug product. Testing for these contaminants is critical in every part of pharmaceutical packaging including the packaging system used to store drug products.

PDF 881 KB
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